Drugging the undruggable: Ross Cagan interviews Kevan Shokat

Acute rapamycin treatment reveals distinct mechanisms of dysfunction in a maternal inflammation mouse model.

Nature communications·2026

Single-cell transcriptomic unveils tumor-mediated reprogramming of neutrophils and their unique vulnerability that inhibits metastasis.

Science advances·2026

Benzoxaboroles Are Structurally Unique Binders of Eukaryotic Translation Initiation Factor 4E.

Journal of the American Chemical Society·2026

Single-Sequence Deep Learning Delivers Crystal-Quality Models of Covalent K-Ras G12 Hotspot Complexes.

IUBMB life·2026

The structural basis for LRRK2's activation and autoinhibition.

bioRxiv : the preprint server for biology·2026

Macrophage-Derived PDGF-BB and GDF-15 Promote Drug Resistance in KRAS-Mutant Colorectal Cancer.

bioRxiv : the preprint server for biology·2026

Development of a pediatric pig model of extracorporeal cardiopulmonary resuscitation (ECPR) induced acute kidney injury.

Disease models & mechanisms·2026

Early pre-symptomatic and sex-specific cardiac remodeling precedes heart failure in zebrafish with human actin mutation.

Disease models & mechanisms·2026

Fixed-dose streptozotocin combined with high-fat diet induces a stable type 2 diabetes-like phenotype in C57BL/6J mice.

Disease models & mechanisms·2026

Cystic fibrosis: insights from zebrafish models.

Disease models & mechanisms·2026

Cardiac MRI reveals myocardial fibrosis and systolic dysfunction in mitochondrial trifunctional protein-deficient mice.

Disease models & mechanisms·2026

An improved SMS p.Gly56Ser mouse model of Snyder-Robinson syndrome reveals phenotypic parallels with clinical features.

Disease models & mechanisms·2026

Cytotoxicity Test of Ethyl Acetate Fraction of Gnetum gnemon L. Seeds on Breast and Colon Cancer Cells: Preliminary Investigation of Catechin Compounds.

Journal of pharmacy & bioallied sciences·2026

Strychnine as an Emerging Adulterant in the Illicit Fentanyl Drug Supply.

AJPM focus·2026

Flavonoids as potential anti-asthmatic agents.

Frontiers in immunology·2026

[Expression of Concern] Exogenous spermine attenuates diabetic kidney injury in rats by inhibiting AMPK/mTOR signaling pathway.

International journal of molecular medicine·2026

Resolution and Quantitation of Ribonucleosides and Deoxyribonucleosides in Digested Genomic DNA by UHPLC-MS/MS.

Biomedical chromatography : BMC·2026

NMDA receptor subunit-dependent analysis of radiprodil inhibition in neonatal male rat substantia nigra dopaminergic neurons.

British journal of pharmacology·2026

Related Experiment Videos

Drugging the undruggable: Ross Cagan interviews Kevan Shokat

Related Concept Videos

Acute rapamycin treatment reveals distinct mechanisms of dysfunction in a maternal inflammation mouse model.

Single-cell transcriptomic unveils tumor-mediated reprogramming of neutrophils and their unique vulnerability that inhibits metastasis.

Benzoxaboroles Are Structurally Unique Binders of Eukaryotic Translation Initiation Factor 4E.

Single-Sequence Deep Learning Delivers Crystal-Quality Models of Covalent K-Ras G12 Hotspot Complexes.

The structural basis for LRRK2's activation and autoinhibition.

Macrophage-Derived PDGF-BB and GDF-15 Promote Drug Resistance in KRAS-Mutant Colorectal Cancer.

Development of a pediatric pig model of extracorporeal cardiopulmonary resuscitation (ECPR) induced acute kidney injury.

Early pre-symptomatic and sex-specific cardiac remodeling precedes heart failure in zebrafish with human actin mutation.

Fixed-dose streptozotocin combined with high-fat diet induces a stable type 2 diabetes-like phenotype in C57BL/6J mice.

Cystic fibrosis: insights from zebrafish models.

Cardiac MRI reveals myocardial fibrosis and systolic dysfunction in mitochondrial trifunctional protein-deficient mice.

An improved SMS p.Gly56Ser mouse model of Snyder-Robinson syndrome reveals phenotypic parallels with clinical features.

Cytotoxicity Test of Ethyl Acetate Fraction of Gnetum gnemon L. Seeds on Breast and Colon Cancer Cells: Preliminary Investigation of Catechin Compounds.

Strychnine as an Emerging Adulterant in the Illicit Fentanyl Drug Supply.

Flavonoids as potential anti-asthmatic agents.

[Expression of Concern] Exogenous spermine attenuates diabetic kidney injury in rats by inhibiting AMPK/mTOR signaling pathway.

Resolution and Quantitation of Ribonucleosides and Deoxyribonucleosides in Digested Genomic DNA by UHPLC-MS/MS.

NMDA receptor subunit-dependent analysis of radiprodil inhibition in neonatal male rat substantia nigra dopaminergic neurons.

Related Experiment Videos

Drugging the undruggable: Ross Cagan interviews Kevan Shokat

Related Concept Videos

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