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A review on the current status and definitions of activity indices in inflammatory bowel disease: how to use indices

Masahiro Kishi1, Fumihito Hirai2, Noritaka Takatsu1

  • 1Inflammatory Bowel Disease Center, Fukuoka University Chikushi Hospital, Chikushino, Japan.

Journal of Gastroenterology
|March 2, 2022
PubMed

Many clinical trials have been conducted for inflammatory bowel disease (IBD), so various clinical indices (CIs) and endoscopic indices (EIs) have also been evaluated. However, recently, with the progress of IBD management, review of established indices from previous studies, and establishment of new indices, the landscape of the use of indices in clinical trials have changed. We investigated the number and frequency of the indices adapted in recent clinical trials for ulcerative colitis (CI and EI) and Crohn's disease (CI, EI, index related to magnetic resonance imaging, index for evaluating patient-reported outcomes, and health-related quality of life). Based on the results, we selected representative indices and further reviewed their content and characteristics. Moreover, various definitions, including clinical and endoscopic response or remission, have been described by means of representative indices in clinical trials.

Keywords:
Clinical indexCrohn’s diseaseEndoscopic indexInflammatory bowel diseaseUlcerative colitis

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