Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

718
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
718
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

2.9K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
2.9K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

9.5K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
9.5K
Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

997
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
997
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

75
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
75
Proteoglycans01:05

Proteoglycans

4.1K
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Melatonin improves mitochondrial function and redox balance in human cartilage endplate-derived stem cells.

Cytotechnology·2026
Same author

A manganese-luteolin co-loaded antioxidant hydrogel for synergistic alleviation of oxidative stress and immunomodulation in intervertebral disc degeneration.

Materials today. Bio·2026
Same author

Long-tailed multi-label retinal disease classification using alternate group training and gradient-based re-weighting.

Scientific reports·2026
Same author

The role of the gut-spinal axis in immune-metabolic coupling after spinal cord injury.

International immunopharmacology·2026
Same author

Fluctuation-Based Super-Resolution Microscopy Classification via Gradient Boosting Decision Trees.

Microscopy research and technique·2026
Same author

Comprehensive transcriptome and metabolome analyses reveal dynamic changes in quality and anti-stress strategy of Volvariella volvacea during storage.

Food chemistry·2026

Related Experiment Video

Updated: Oct 1, 2025

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
11:52

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Published on: January 27, 2023

3.6K

Osteopontin in autoimmune disorders: current knowledge and future perspective.

Canhua Xu1, Yaohong Wu1, Ning Liu2

  • 1Department of Spine Surgery, Ganzhou People's Hospital, No. 16, Meiguan Avenue, Zhanggong District, Ganzhou, 341000, Jiangxi, China.

Inflammopharmacology
|March 2, 2022
PubMed
Summary

Osteopontin (OPN) is an immune regulator implicated in autoimmune diseases. This review details OPN's role in conditions like rheumatoid arthritis and lupus, highlighting its correlation with disease severity.

Keywords:
AutoimmunityIBDLupusOsteopontinRheumatoid arthritis

More Related Videos

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

9.6K
A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research
08:17

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research

Published on: August 15, 2019

14.7K

Related Experiment Videos

Last Updated: Oct 1, 2025

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
11:52

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Published on: January 27, 2023

3.6K
Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

9.6K
A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research
08:17

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research

Published on: August 15, 2019

14.7K

Area of Science:

  • Immunology
  • Molecular Biology
  • Biochemistry

Background:

  • Osteopontin (OPN) is a cytokine and adhesion molecule regulating innate and adaptive immunity.
  • OPN is produced by immune cells like dendritic cells, macrophages, and T lymphocytes.
  • Elevated OPN expression is observed in various conditions, including autoimmunity, cancer, and allergies.

Purpose of the Study:

  • To review the role of Osteopontin (OPN) in autoimmune disorders.
  • To provide a comprehensive overview of current knowledge on OPN in autoimmunity.

Main Methods:

  • Literature review of studies investigating Osteopontin (OPN).
  • Analysis of OPN expression levels in relation to autoimmune disease severity.
  • Synthesis of information on OPN's regulatory functions in immune responses.

Main Results:

  • OPN overexpression is linked to increased severity in autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), Type 1 diabetes (T1D), inflammatory bowel disease (IBD), Sjögren's syndrome, and myasthenia gravis.
  • OPN's multifunctional nature impacts both innate and adaptive immune pathways.
  • Specific immune cells like DCs, macrophages, and T lymphocytes are key producers of OPN.

Conclusions:

  • Osteopontin (OPN) plays a significant role in the pathogenesis and progression of autoimmune disorders.
  • Understanding OPN's function is crucial for developing targeted therapies for autoimmune conditions.
  • Further research into OPN's regulatory mechanisms could offer new therapeutic strategies.