Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitochondrial Membranes01:45

Mitochondrial Membranes

12.6K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
12.6K
The Inner Mitochondrial Membrane01:28

The Inner Mitochondrial Membrane

3.7K
The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria.  In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
3.7K
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

52
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
52
Mitochondria01:37

Mitochondria

15.4K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
15.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Repeat Surgery after Percutaneous Endoscopic Lumbar Discectomy for Adolescent Lumbar Disc Herniation: A Multicenter Observational Study.

Orthopaedic surgery·2024
Same author

Ameliorative effects of resveratrol against cadmium-induced nephrotoxicity via modulating nuclear xenobiotic receptor response and PINK1/Parkin-mediated Mitophagy.

Food & function·2020
Same author

`Cadmium induced cardiac inflammation in chicken (Gallus gallus) via modulating cytochrome P450 systems and Nrf2 mediated antioxidant defense.

Chemosphere·2020
Same author

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury.

Science China. Life sciences·2020
Same author

Orlistat delays hepatocarcinogenesis in mice with hepatic co-activation of AKT and c-Met.

Toxicology and applied pharmacology·2020
Same author

A Zr-cluster based thermostable, self-healing and adaptive metallogel with chromogenic properties responds to multiple stimuli with reversible radical interaction.

Chemical communications (Cambridge, England)·2020

Related Experiment Video

Updated: Oct 1, 2025

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits
06:03

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits

Published on: July 21, 2023

643

Update on the Correlation Between Mitochondrial Dysfunction and Intervertebral Disk Degeneration.

Cong Zhang1,2, Xin Peng1,2, Feng Wang1

  • 1Department of Spine Surgery, School of Medicine, Southeast University, Zhongda Hospital, Nanjing, China.

DNA and Cell Biology
|March 2, 2022
PubMed
Summary
This summary is machine-generated.

Mitochondrial dysfunction contributes to low back pain and intervertebral disc degeneration. Understanding these mechanisms may lead to new treatments for chronic low back pain.

Keywords:
intervertebral disk degenerationmitochondrial dysfunctionmitophagyoxidative stress

More Related Videos

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
08:19

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry

Published on: May 5, 2022

2.6K
A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
05:46

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

Published on: February 14, 2021

3.8K

Related Experiment Videos

Last Updated: Oct 1, 2025

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits
06:03

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits

Published on: July 21, 2023

643
Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
08:19

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry

Published on: May 5, 2022

2.6K
A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
05:46

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

Published on: February 14, 2021

3.8K

Area of Science:

  • Orthopedics
  • Cell Biology
  • Biochemistry

Background:

  • Low back pain (LBP) is a prevalent orthopedic condition affecting all ages, with potential for chronicity.
  • Mitochondria, crucial for energy and cellular processes like senescence and apoptosis, play a key role in maintaining tissue homeostasis.
  • Mitochondrial dysfunction is increasingly implicated in the pathophysiology of various degenerative diseases.

Purpose of the Study:

  • To review the molecular mechanisms linking mitochondrial dysfunction to intervertebral disc degeneration (IDD).
  • To provide a theoretical foundation for developing novel therapeutic strategies for IDD.

Main Methods:

  • Literature review focusing on molecular mechanisms.
  • Analysis of the role of mitochondria in cellular processes relevant to IDD.
  • Synthesis of information on oxidative stress, mitophagy, and homeostasis in IDD.

Main Results:

  • Mitochondrial dysfunction impacts multiple pathophysiological pathways in IDD.
  • Key processes affected include oxidative stress, mitophagy, mitochondrial homeostasis, cellular senescence, and apoptosis.
  • These dysfunctions collectively contribute to the progression of intervertebral disc degeneration.

Conclusions:

  • Mitochondrial dysfunction is a significant driver of intervertebral disc degeneration.
  • Targeting mitochondrial pathways offers potential for pharmacological and tissue-engineering treatments for LBP and IDD.