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Updated: Oct 1, 2025

A Label-Free Segmentation Approach for Intravital Imaging of Mammary Tumor Microenvironment
Published on: May 24, 2022
Epigenetic regulation and targeting of ECM for cancer therapy
Romi Gupta1,2
1Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, Birmingham, Alabama.
Abstract:
The tumor microenvironment (TME) composed of different types of cells embedded in extracellular matrix (ECM) has crucial effects on cancer growth and metastasis. ECM is made of a variety of proteins that provide structural support to the cells and regulate biological functions by modulating the cross talk among cells, thus effecting tumor growth and progression. In this mini-review, the author discusses epigenetic modifications that regulate the expression of fibrous ECM proteins and glycoproteins and the prospects of targeting them for cancer therapy.
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