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Updated: Oct 1, 2025

Cholesterol Efflux Assay
Published on: March 6, 2012
Reverse cholesterol transport and hepatic osteodystrophy
Mone Zaidi1, Tony Yuen1, Jameel Iqbal1
1Mount Sinai Bone Program and Center for Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Abstract:
In this issue of Cell Metabolism, Lu et al. show that chronic liver disease increases the expression and activity of PP2Ac, a phosphatase that downregulates the excretion of lecithin-cholesterol aceyltransferase (LCAT). LCAT, a liver-derived enzyme, protects bone and prevents bone loss, and its lowered levels in progressive liver injury cause hepatic osteodystrophy (HOD) and worsen liver fibrosis. These discoveries open the possibility that recombinant LCAT may be a treatment for both HOD and liver fibrosis.
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