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A clinical profile of infective endocarditis in patients with recent COVID-19: A systematic review

Juan A Quintero-Martinez1, Joya-Rita Hindy1, Maryam Mahmood1

  • 1Division of Infectious Diseases, Departments of Medicine and Cardiovascular Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.

The American Journal of the Medical Sciences
|March 2, 2022
PubMed

Insights

Infective endocarditis (IE) is a potential complication following Coronavirus disease 2019 (COVID-19). This systematic review characterizes IE in COVID-19 patients, revealing key clinical features and outcomes.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Coronavirus disease 2019 (COVID-19) is associated with cardiovascular complications and increased mortality.
  • Infective endocarditis (IE) is a recognized complication in patients with recent COVID-19 infections.
  • Limited characterization exists for IE following COVID-19 infection.

Purpose of the Study:

  • To systematically review and analyze the clinical features and outcomes of infective endocarditis (IE) in patients with a history of COVID-19.
  • To provide a comprehensive profile of IE as a complication of COVID-19.

Main Methods:

  • A systematic review of 8 databases was conducted for published reports of IE in patients with confirmed COVID-19.
  • Data extraction included clinical characteristics, microbiological findings, outcomes, and procedures based on modified Duke criteria.

Main Results:

  • Twenty articles comprising 323 reports met inclusion criteria, with a mean patient age of 52.2 years (76.2% male).
  • Staphylococcus aureus was the most common pathogen (38.1%). The mean interval between COVID-19 and IE diagnosis was 16.7 days.
  • Twenty-eight percent required critical care, 33.3% underwent cardiac surgery, and 23.8% died during hospitalization.

Conclusions:

  • This systematic review outlines the clinical profile and outcomes of IE post-COVID-19 infection.
  • Clinicians must recognize IE as a potential and unique complication of COVID-19, especially during the ongoing pandemic.
Abstract

Keywords:
COVID-19Infective endocarditisOutcomesSARS-CoV-2

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