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Updated: Oct 1, 2025

In Vitro Canine Neutrophil Extracellular Trap Formation: Dynamic and Quantitative Analysis by Fluorescence Microscopy
Published on: August 24, 2018
[Life-threatening acute neutrophilic vasculitis in a Shar-Pei puppy]
Christiane Weingart1, Olivia Kershaw2, Barbara Kohn1
1Klinik für kleine Haustiere, Fachbereich Veterinärmedizin, Freie Universität Berlin.
Abstract:
A 3-month old male Shar-Pei was presented for lethargy, fever and cutaneous edema. Further investigations revealed superficial pyoderma with Streptococcus canis and an acute neutrophilic vasculitis. Symptomatic and antibiotic treatment in combination with immunosuppressive treatment (initially prednisolone, later cyclosporine) treatment was performed. In the course of the disease complications such as dyspnea, anemia, skin ulceration, skin necrosis and secondary bacterial skin infection with multiresistant bacteria occurred. After intensive care treatment the dog was discharged from the hospital 38 days later. Within the following weeks the dosage of the immunosuppressants were reduced and the drugs were discontinued after 4 months.
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