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A New Murine Model of Endovascular Aortic Aneurysm Repair
Published on: July 7, 2013
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Persisting Type 2 Endoleaks Following EVAR for AAA Are Associated With AAA Expansion
Johannes Hatzl1, Vivian Wang1, Maani Hakimi2
1Department of Vascular and Endovascular Surgery, University Hospital Heidelberg, Heidelberg, Germany.
Summary
Persisting type 2 endoleaks (pEL2) after endovascular abdominal aortic aneurysm repair (EVAR) are linked to abdominal aortic aneurysm (AAA) expansion. Further research is needed to guide treatment indications for pEL2.
Area of Science:
- Vascular Surgery
- Endovascular Repair
- Aortic Aneurysm Management
Background:
- Endovascular abdominal aortic aneurysm repair (EVAR) is a common treatment for abdominal aortic aneurysms (AAA).
- Type 2 endoleaks (EL2) can persist after EVAR, potentially impacting AAA sac behavior.
- Understanding the long-term implications of persisting type 2 endoleaks (pEL2) is crucial for patient management.
Purpose of the Study:
- To investigate the evolution of abdominal aortic aneurysm (AAA) diameter in patients with persisting type 2 endoleaks (pEL2) after EVAR.
- To compare AAA diameter changes between patients with pEL2 and a matched control group without endoleaks.
Main Methods:
- Retrospective, single-center, case-control study.
- Identified patients with pEL2 (>12 months) and matched them 1:1 with controls.
- Assessed freedom from AAA expansion and shrinkage using computed tomography angiography (CTA) over time.
Main Results:
- Patients with pEL2 showed significantly higher rates of AAA expansion compared to controls over 4 years (p<0.01).
- Freedom from AAA shrinkage was also significantly different between groups (p<0.01).
- No significant difference in overall survival or AAA-related mortality was observed between groups.
Conclusions:
- Persisting type 2 endoleaks (pEL2) are associated with abdominal aortic aneurysm (AAA) expansion in the midterm follow-up.
- Further studies are required to evaluate the clinical outcomes associated with AAA expansion due to pEL2.
- Recommendations for treatment indications for pEL2 require further investigation.
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