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Related Concept Videos

Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
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Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

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Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
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COPD: Management Using Bronchodilators and Corticosteroids01:26

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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Asthma-IV: Nursing Management01:30

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The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Asthma-III: Symptoms and Complications01:24

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Dexamethasone for Pediatric Critical Asthma: A Multicenter Descriptive Study.

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Dexamethasone prescribing is increasing for pediatric critical asthma, showing reduced severity and fewer adverse events compared to methylprednisolone. Further research is needed to determine optimal corticosteroid regimens.

Keywords:
corticosteroidscritical asthmadexamethasonemethylprednisolonepediatric intensive care unitpediatricsstatus asthmaticus

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Area of Science:

  • Pediatric Critical Care Medicine
  • Pharmacology
  • Respiratory Medicine

Background:

  • Systemic corticosteroids are crucial for managing severe pediatric asthma.
  • Intravenous methylprednisolone is common, but dexamethasone is emerging as an alternative.
  • This study examines corticosteroid prescribing trends in pediatric intensive care units.

Purpose of the Study:

  • To assess trends and variations in corticosteroid prescribing for critical asthma in children.
  • To compare outcomes associated with different corticosteroid regimens.

Main Methods:

  • Multicenter retrospective cohort study using the Pediatric Health Information System (PHIS) registry.
  • Included children aged 3-17 years admitted for critical asthma from 2011-2019.
  • Analyzed corticosteroid prescribing rates, adverse events, interventions, mortality, and length of stay.

Main Results:

  • Dexamethasone prescribing increased by 0.5% annually, with dexamethasone-alone use at 2.4%.
  • Dexamethasone-alone was associated with reduced asthma severity, shorter hospital stays, and fewer adjunctive treatments.
  • Adverse events like gastritis and hyperglycemia were less frequent with dexamethasone-alone.

Conclusions:

  • Dexamethasone prescribing is rising for pediatric critical asthma.
  • Variability in prescribing suggests a need for prospective studies to establish ideal corticosteroid regimens.