Sepsis, Septic Shock, and Differences in Cardiovascular Event Occurrence.

Area of Science:

• Critical Care Medicine
• Cardiology
• Epidemiology

Background:

• Sepsis and septic shock carry high mortality rates, with limited data on cardiovascular complications in septic shock patients.
• Cardiovascular events in sepsis patients are linked to increased mortality, necessitating further investigation in severe cases.

Purpose of the Study:

• To compare in-hospital mortality, cardiovascular events, and procedures in sepsis patients with and without subsequent septic shock.
• To provide updated data on the impact of septic shock on cardiovascular outcomes.

Main Methods:

• Utilized the 2016-2017 National Readmissions Database to identify sepsis patients.
• Stratified patients based on the presence or absence of a secondary diagnosis of septic shock.
• Analyzed in-hospital mortality, incident cardiovascular events, and cardiovascular procedures.

Main Results:

• A total of 2,127,137 patients were analyzed; 20% developed subsequent septic shock.
• In-hospital mortality was 5.3% for sepsis and 31.2% for sepsis with subsequent septic shock.
• Sepsis with septic shock showed higher rates of acute kidney injury, heart failure, NSTEMI, ischemic stroke, and cardiovascular procedures.

Conclusions:

• Subsequent septic shock significantly increases the frequency of in-hospital cardiovascular events and procedures in sepsis patients.
• These findings underscore the severe cardiovascular burden associated with septic shock.