Can urinary CTX-II be a biomarker for knee osteoarthritis?
Piti Arunrukthavon1,2, Danai Heebthamai1, Prapasri Benchasiriluck3
1Department of Orthopedic Surgery, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand.
Arthroplasty (London, England)
|March 3, 2022
Summary
Urinary C-terminal cross-linked telopeptide of type II collagen (CTX-II) is elevated in knee osteoarthritis patients. Higher CTX-II levels correlate with radiographic severity, aiding in early OA diagnosis.
Area of Science:
- Biochemistry
- Orthopedics
- Rheumatology
Background:
- Early diagnosis of knee osteoarthritis (OA) is challenging.
- Urinary C-terminal cross-linked telopeptide of type II collagen (urinary CTX-II) shows potential as an OA biomarker.
- Conclusive evidence for urinary CTX-II in early OA diagnosis is lacking.
Purpose of the Study:
- Compare urinary CTX-II levels in knee OA patients versus healthy controls.
- Evaluate the correlation between urinary CTX-II, OA radiographic severity, and patient-reported outcomes.
- Assess the influence of age and gender on urinary CTX-II levels in Asian populations.
Main Methods:
- Study included 78 knee OA patients and 51 healthy controls, all over 40.
- Radiographs were graded using the Kellgren and Lawrence (KL) system.
- Urinary CTX-II measured by ELISA; Western Ontario and McMaster Universities Arthritis Index (WOMAC) recorded.
Main Results:
- Urinary CTX-II levels were significantly higher in the OA group (p < 0.001).
- A moderate correlation was found between urinary CTX-II and KL grades (r=0.405, p < 0.001).
- Urinary CTX-II was independently associated with KL grades, unaffected by age, gender, or WOMAC scores.
Conclusions:
- Knee OA patients exhibit elevated urinary CTX-II levels compared to healthy individuals.
- Urinary CTX-II levels are independently correlated with the radiographic severity of knee OA.
- Age, gender, and patient-reported outcomes did not significantly affect urinary CTX-II levels.
Related Concept Videos
01:30Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
59
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
59
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
56
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
56
01:24Imaging Studies II: Ultrasonography
73
IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...
73
01:29Urine Studies I: Urinalysis
266
Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
266
01:26Urine Studies II: Urine Culture and Sensitivity Test
173
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
173
01:22Imaging Studies VI: Voiding Cystourethrography and Cystography
198
Voiding Cystourethrography (VCUG) and Cystography are specialized radiographic procedures used to examine the structure and function of the bladder and urethra.Voiding Cystourethrography (VCUG)A Voiding Cystourethrogram (VCUG) is a diagnostic imaging procedure that assesses the anatomy and function of the lower urinary tract. It focuses on the bladder, bladder neck, and urethra, helping detect abnormalities such as vesicoureteral reflux (VUR)—the backward or reverse flow of urine into the...
198