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Targeting Inflammation in Bronchiectasis.

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Design and rationale of the AIR-NET trial: a randomised, open-label, multifactorial, multicentre, adaptive platform trial using a range of repurposed anti-inflammatory treatments to improve outcomes in patients with bronchiectasis within the EMBARC clinical research network.

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Determining Ciliary Function and Membrane Impermeability of the Pseudostratified Lung Airway Epithelium
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Bronchiectasis from 2012 to 2022.

James D Chalmers1

  • 1Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, UK.

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Summary
This summary is machine-generated.

Bronchiectasis research has advanced significantly, moving beyond "orphan disease" status. New insights into epidemiology and increased clinical trials are improving treatment evidence, but further work is needed for better patient outcomes.

Keywords:
BronchiectasisClinical trialsEpidemiologyGuidelines

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Area of Science:

  • Pulmonology and Respiratory Medicine
  • Clinical Research and Epidemiology

Background:

  • Bronchiectasis was previously considered an
  • orphan disease
  • with limited research focus.
  • Significant advancements in understanding bronchiectasis have occurred in the last decade.
  • The field has seen a resurgence, indicating growing clinical and research interest.

Purpose of the Study:

  • To review the recent progress in bronchiectasis research.
  • To highlight key developments in epidemiology and treatment evidence.
  • To identify areas for future research to improve patient outcomes.

Main Methods:

  • Review of recent literature and clinical trial data in bronchiectasis.
  • Analysis of epidemiological trends and the impact of international registries.
  • Assessment of the evidence base for current and emerging treatments.

Main Results:

  • Bronchiectasis is no longer considered an
  • orphan disease
  • due to increased research.
  • Epidemiological understanding has deepened with the establishment of international registries.
  • A substantial increase in randomized clinical trials has strengthened treatment evidence.

Conclusions:

  • Bronchiectasis research has experienced a renaissance, marked by improved epidemiological data and robust clinical trial evidence.
  • Despite progress, translating research findings into improved patient outcomes remains a critical challenge.
  • Continued global interest and research are essential for advancing the management of bronchiectasis.