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Updated: Oct 1, 2025

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
Published on: August 8, 2025
Coronary access after transcatheter aortic valve replacement in bicuspid versus tricuspid aortic stenosis
Insights
Coronary access after transcatheter aortic valve replacement (TAVR) can be challenging. Type 0 bicuspid aortic valve (BAV) anatomy appears more favorable for post-TAVR coronary access compared to tricuspid aortic valves (TAV).
Area of Science:
- Cardiology
- Interventional Cardiology
- Biomedical Engineering
Background:
- Coronary access post-transcatheter aortic valve replacement (TAVR) differences between bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV) anatomy are unknown.
- Understanding these differences is crucial for procedural planning and patient outcomes.
Purpose of the Study:
- To investigate and compare coronary access after TAVR using a self-expanding transcatheter heart valve (THV).
- To evaluate access in patients with bicuspid aortic valves (BAV) versus tricuspid aortic valves (TAV) using computed tomography (CT) simulation.
Main Methods:
- CT simulation analysis of 86 type 0 BAV, 70 type 1 BAV, and 132 TAV patients.
- Defined challenging coronary access based on THV or native leaflet interference.
- Defined complex coronary access if coaxial engagement was hindered by the unwrapped frame.
Main Results:
- THV-related challenging coronary access occurred in 21.2% (LCA) and 17.7% (RCA).
- Type 0 BAV patients had less THV-related challenging LCA access than TAV patients (OR 0.42).
- Optimal fluoroscopic angles for RCA engagement were significantly higher in type 0 BAV patients.
Conclusions:
- Coronary access can be challenging or complex in a significant number of BAV and TAV patients post-TAVR.
- Type 0 BAV anatomy may offer a more favorable profile for post-TAVR coronary access.
Background:
It is unknown whether there are differences in coronary access after transcatheter aortic valve replacement (TAVR) between bicuspid and tricuspid anatomy.
Aims:
Our aim was to investigate coronary access after TAVR using a self-expanding transcatheter heart valve (THV) in bicuspid versus tricuspid aortic valves (BAV vs TAV), based on CT simulation.
Methods:
A total of 86 type 0 BAV, 70 type 1 BAV, and 132 TAV patients were included. If the coronary ostium faced the sealed parts of the THV or the tilted-up native leaflet (NL), this was defined as THV- or NL-related challenging coronary access, respectively. If coaxial engagement was not allowed due to interference from the unwrapped frame, THV-related complex coronary access was defined.
Results:
The incidence of THV-related challenging coronary access was 21.2% for the left coronary artery (LCA) and 17.7% for the right coronary artery (RCA), and type 0 BAV patients encountered fewer THV-related challenging LCA access than their TAV counterparts (OR 0.42, 95% CI: 0.20-0.89). NL-related challenging coronary access was observed in 3.1% for LCA and 1.4% for RCA, and THV-related complex coronary access was identified in 5.9% for LCA and 17.0% for RCA; however, no significant differences were found among groups. The proportion of optimal fluoroscopic viewing angles suitable for guiding LCA engagement was similar among groups (64.0% vs 70.0% vs 62.1%), but those suitable for guiding RCA engagement were significantly higher in the type 0 BAV group (31.4% vs 4.3% vs 9.1%).
Conclusions:
Coronary access may be challenging or complex in a significant proportion of both BAV and TAV patients after TAVR. Type 0 BAV anatomy may be more favourable for post-TAVR coronary access.
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