Related Experiment Video

Updated: Oct 1, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

12.9K

Clinical Relevance of the Constitutive Androstane Receptor

Sydney Stern1, Ritika Kurian1, Hongbing Wang2

  • 1Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland.

Drug Metabolism and Disposition: the Biological Fate of Chemicals
|March 3, 2022
PubMed

Insights

The constitutive androstane receptor (CAR) is crucial for drug detoxification and also impacts glucose, lipid, and bile acid metabolism. Understanding CAR

Area of Science:

  • Pharmacology and Toxicology
  • Molecular Biology
  • Metabolic Diseases

Background:

  • The constitutive androstane receptor (CAR) (NR1I3) is a key regulator of drug metabolism and detoxification.
  • Emerging evidence highlights CAR's role in physiological processes like glucose, lipid, and bile acid homeostasis.
  • CAR is implicated in cell proliferation, tissue repair, and cancer development.

Purpose of the Study:

  • To review the multifaceted roles of CAR beyond drug metabolism.
  • To summarize CAR's contribution to metabolic disorders and cancer.
  • To discuss challenges in targeting CAR therapeutically.

Main Methods:

  • Literature review of current research on CAR function.
  • Analysis of CAR's involvement in metabolic pathways.
  • Examination of CAR's role in oncogenesis and disease.

Main Results:

  • CAR significantly influences glucose, lipid, and bile acid metabolism.
  • CAR activity is modulated by various factors including small molecules and genetic variants.
  • CAR plays a role in cell proliferation, regeneration, and cancer development.

Conclusions:

  • CAR's influence extends to metabolic homeostasis and disease pathology.
  • Targeting CAR presents potential therapeutic avenues for metabolic disorders and cancer.
  • Further research is needed to fully elucidate CAR's clinical relevance and therapeutic potential.

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