Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Targeting Oxidative Stress during the Post-Thawing Recovery Window Improves Cryopreservation Outcomes in Human Neural Organoids.

International journal of stem cells·2026

Same author

Organoid Technology as a Promising Frontier in Organ Transplantation and Regenerative Medicine.

International journal of stem cells·2025

Same author

HELLS controls mitochondrial dynamics and genome stability in liver cancer by collusion with MIEF1.

Cell death & disease·2025

Same author

Toxicity assessment using neural organoids: innovative approaches and challenges.

Toxicological research·2025

Same author

The Differential Developmental Neurotoxicity of Valproic Acid on Anterior and Posterior Neural Induction of Human Pluripotent Stem Cells.

International journal of stem cells·2024

Same author

Guidelines for Manufacturing and Application of Organoids: Brain.

International journal of stem cells·2024

Search research articles

Related Experiment Video

Updated: Oct 1, 2025

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

Neural Organoids, a Versatile Model for Neuroscience.

Ju-Hyun Lee¹, Woong Sun¹

¹Department of Anatomy, Brain Korea 21 Plus Program for Biomedical Science, Korea University College of Medicine, Seoul 02841, Korea.

Molecules and Cells

|March 3, 2022

Summary

Neural organoids, 3D human brain models grown in vitro, offer promise for understanding brain development, disease modeling, and drug discovery. Researchers are exploring their applications while acknowledging current technical limitations.

Keywords:

central nervous system human pluripotent stem cells neurodevelopment neurological disorders organoid

More Related Videos

A Human Cerebral Organoid Model of Neural Cell Transplantation

A Human Cerebral Organoid Model of Neural Cell Transplantation

Published on: July 21, 2023

Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro

Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro

Published on: May 5, 2022

Related Experiment Videos

Last Updated: Oct 1, 2025

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

A Human Cerebral Organoid Model of Neural Cell Transplantation

A Human Cerebral Organoid Model of Neural Cell Transplantation

Published on: July 21, 2023

Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro

Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro

Published on: May 5, 2022

Area of Science:

Neuroscience
Developmental Biology
Biotechnology

Background:

Three-dimensional cultures of human neural tissue, known as neural organoids, are created by mimicking in vivo developmental processes.
Significant advancements in neural organoid technology have generated excitement for various biomedical applications.

Purpose of the Study:

To review the current state-of-the-art applications of neural organoids in research.
To discuss the practical realities and limitations of neural organoid technology.

Main Methods:

Mimicking in vivo developmental processes to generate 3D human neural tissue/organoids in vitro.
Summarizing existing research and applications of neural organoids.

Main Results:

Neural organoids show potential in understanding brain development and function.
Applications include modeling neurological diseases, drug discovery, and transplantation research.

Conclusions:

Neural organoids are a powerful tool with diverse research applications.
Ongoing research aims to overcome current limitations for broader utility.