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Updated: Oct 1, 2025

Whole Cell Recording from an Organotypic Slice Preparation of Neocortex
Published on: June 3, 2011
Orchestration of Ion Channels and Transporters in Neocortical Development and Neurological Disorders
Yuki Bando1, Masaru Ishibashi2, Satoru Yamagishi1
1Department of Organ and Tissue Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Abstract:
Electrical activity plays crucial roles in neural circuit formation and remodeling. During neocortical development, neurons are generated in the ventricular zone, migrate to their correct position, elongate dendrites and axons, and form synapses. In this review, we summarize the functions of ion channels and transporters in neocortical development. Next, we discuss links between neurological disorders caused by dysfunction of ion channels (channelopathies) and neocortical development. Finally, we introduce emerging optical techniques with potential applications in physiological studies of neocortical development and the pathophysiology of channelopathies.
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