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Multiple endocrine neoplasia 2: an overview.

B Saravana-Bawan¹, J D Pasternak²

¹University Health Network, University of Toronto, Toronto, ON, Canada.

Therapeutic Advances in Chronic Disease

|March 3, 2022

Summary

Multiple Endocrine Neoplasia type 2 (MEN2) involves tumors of the parathyroid, thyroid, and adrenal glands. This review covers MEN2

Keywords:

MEN2 hyperparathyroidism medullary thyroid cancer multiple endocrine neoplasia pheochromocytoma

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Area of Science:

Endocrinology
Oncology
Genetics

Background:

Multiple Endocrine Neoplasia type 2 (MEN2) is a rare genetic disorder.
It predisposes individuals to developing tumors in endocrine glands.

Purpose of the Study:

To provide a comprehensive overview of MEN2.
To detail clinical manifestations, diagnosis, and management strategies.

Main Methods:

Literature review of existing studies on MEN2.
Synthesis of information on clinical phenotypes, genetics, and treatment.

Main Results:

MEN2 commonly affects the parathyroid, thyroid (medullary thyroid carcinoma), and adrenal glands (pheochromocytoma).
Characteristic clinical features aid in diagnosis.
Genetic screening is crucial for early detection.

Conclusions:

Early diagnosis and proactive management are essential for improving outcomes in MEN2 patients.
Multidisciplinary care is recommended for optimal surveillance and treatment.