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Multiple endocrine neoplasia 2: an overview

B Saravana-Bawan1, J D Pasternak2

  • 1University Health Network, University of Toronto, Toronto, ON, Canada.

Therapeutic Advances in Chronic Disease
|March 3, 2022
PubMed

Insights

Multiple Endocrine Neoplasia type 2 (MEN2) involves tumors of the parathyroid, thyroid, and adrenal glands. This review covers MEN2

Area of Science:

  • Endocrinology
  • Oncology
  • Genetics

Background:

  • Multiple Endocrine Neoplasia type 2 (MEN2) is a rare genetic disorder.
  • It predisposes individuals to developing tumors in endocrine glands.

Purpose of the Study:

  • To provide a comprehensive overview of MEN2.
  • To detail clinical manifestations, diagnosis, and management strategies.

Main Methods:

  • Literature review of existing studies on MEN2.
  • Synthesis of information on clinical phenotypes, genetics, and treatment.

Main Results:

  • MEN2 commonly affects the parathyroid, thyroid (medullary thyroid carcinoma), and adrenal glands (pheochromocytoma).
  • Characteristic clinical features aid in diagnosis.
  • Genetic screening is crucial for early detection.

Conclusions:

  • Early diagnosis and proactive management are essential for improving outcomes in MEN2 patients.
  • Multidisciplinary care is recommended for optimal surveillance and treatment.
Keywords:
MEN2hyperparathyroidismmedullary thyroid cancermultiple endocrine neoplasiapheochromocytoma

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