Modelling haemoglobin incremental loss on chronic red blood cell transfusions

Understanding the impact of red blood cell (RBC) lifespan, initial RBC removal, and transfusion intervals on patient haemoglobin (Hb) levels and total iron exposure is not accessible for chronic transfusion scenarios. This article introduces the first model to help clinicians optimize chronic transfusion intervals to minimize transfusion frequency.

Hb levels and iron exposure from multiple transfusions were calculated from Weibull residual lifespan distributions, the fraction effete RBC removed within 24-h (X_e ) and the nominal Hb increment. Two-unit transfusions of RBCs initiated at patient [Hb] = 7 g/dl were modelled for different RBC lifespans and transfusion intervals from 18 to 90 days, and X_e from 0.1 to 0.5.

Increased X_e requires shorter transfusion intervals to achieve steady-state [Hb] of 9 g/dl as follows: 30 days between transfusions at X_e  = 0.5, 36 days at X_e  = 0.4, 42 days at X_e  = 0.3, 48 days at X_e  = 0.2 and 54 days at X_e  = 0.1. The same transfusion interval/X_e pairs result in a steady-state [Hb] = 8 g/dl when the RBC lifespan was halved. By reducing transfused RBC increment loss from 30% to 10%, annual transfusions were decreased by 22% with iron addition decreased by 24%. Acute dosing of iron occurs at the higher values of X_e on the day after a transfusion event.

Systematic trends in fractional Hb incremental loss X_e have been modelled and have a significant and calculatable impact on transfusion intervals and associated introduction of iron.