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Metabolic syndrome in patients with COPD: Causes and pathophysiological consequences
Monika Fekete1, Gergo Szollosi2, Stefano Tarantini3
11 Department of Public Health, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Physiology International
|March 3, 2022
Summary
Metabolic syndrome (MetS) is highly prevalent in chronic obstructive pulmonary disease (COPD) patients, negatively impacting respiratory function and quality of life. This condition is linked to nutritional status and systemic inflammation.
Area of Science:
- Pulmonary Medicine
- Metabolic Disorders
- Public Health
Background:
- Decreased physical activity is a significant risk factor for metabolic syndrome (MetS).
- MetS substantially impacts the prognosis of chronic obstructive pulmonary disease (COPD).
Purpose of the Study:
- To assess the metabolic consequences of COPD.
- To evaluate MetS prevalence in COPD patients.
- To examine the relationship between MetS and various patient factors.
Main Methods:
- A cross-sectional study of 401 COPD patients was conducted.
- Data collected included anthropometric measurements, respiratory function tests, and laboratory parameters.
- The study took place at the National Koranyi Institute of Pulmonology in Budapest, Hungary.
Main Results:
- MetS was present in 59.1% of COPD patients, with higher prevalence in females (67.6%) than males (49.7%).
- MetS prevalence increased with BMI ≥ 25 kg/m².
- Patients with MetS showed worse FEV1%pred, lower quality of life (CAT scores), and more frequent exacerbations.
Conclusions:
- MetS negatively affects respiratory function and quality of life in COPD patients.
- MetS is associated with increased disease exacerbations.
- Nutritional status and systemic inflammation are linked to MetS in COPD.
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