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Characteristics of a COVID-19 Cohort With Large Vessel Occlusion: A Multicenter International Study

Pascal Jabbour1, Adam A Dmytriw2, Ahmad Sweid1

  • 1Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.

Neurosurgery
|March 3, 2022
PubMed

Insights

COVID-19 patients with large vessel occlusion (LVO) stroke experienced poorer outcomes and less revascularization. This virus independently predicts incomplete treatment and worse results in LVO stroke patients.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Cardiovascular Research

Background:

  • Stroke mechanisms and outcomes in COVID-19 patients differ from non-COVID-19 stroke.
  • Understanding these differences is crucial for effective treatment.

Purpose of the Study:

  • To evaluate the efficacy and outcomes of acute revascularization for large vessel occlusion (LVO) stroke in patients with COVID-19.
  • To compare these outcomes with a historical control group.

Main Methods:

  • International multicenter retrospective study involving 50 stroke centers.
  • Compared 194 COVID-19 patients with acute LVO to 381 historical controls receiving mechanical thrombectomy.

Main Results:

  • COVID-19 patients were younger and had fewer vascular risk factors.
  • Revascularization rates were lower (39.2% vs 67.2%) and poor functional outcomes were higher (79.8% vs 66.7%) in the COVID-19 group.
  • COVID-19 was linked to lower revascularization likelihood (OR: 0.4) and worse outcomes (OR: 2.5).

Conclusions:

  • COVID-19 independently predicts incomplete revascularization and poor outcomes in LVO stroke.
  • COVID-19 patients with LVO exhibited higher morbidity and mortality rates despite being younger with fewer risk factors.
Abstract

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