Related Experiment Video
Updated: Oct 1, 2025

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
The role of genetic testing in prostate cancer screening, diagnosis, and treatment
Claire M de la Calle1, Yasin Bhanji, Christian P Pavlovich
1The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Purpose Of Review:
This review provides an overview of the current role of genetic testing in prostate cancer screening, diagnosis, and treatment.
Recent Findings:
Recent studies have uncovered few but highly penetrant rare pathogenic mutations (RPMs), in genes, such as BRCA2, with strong prostate cancer risk and outcomes associations. Over 260 single nucleotide polymorphisms (SNPs) have also been identified, each associated with small incremental prostate cancer risk and when combined in a polygenic risk score (PRS), they provide strong prostate cancer risk prediction but do not seem to predict outcomes. Tumor tissue sequencing can also help identify actionable somatic mutations in many patients with advanced prostate cancer and inform on their risk of harboring a germline pathogenic mutation.
Summary:
RPM testing, PRS testing, and tumor sequencing all have current and/or potential future roles in personalized prostate cancer care.
More Related Videos
Related Concept Videos
Genetic Screens
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...

