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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

144
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
144
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

59
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
59
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

70
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
70
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

58
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
58
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

56
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

182
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
182

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Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
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Atherosclerosis and multi-organ-associated pathologies.

W Coles Keeter1, Shelby Ma1, Natalie Stahr1

  • 1Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 West Olney Rd, Norfolk, VA, 23507, USA.

Seminars in Immunopathology
|March 3, 2022
PubMed
Summary
This summary is machine-generated.

Atherosclerosis, a vascular disease, impacts numerous organs by altering local immunity and vascular function. Understanding these connections offers new therapeutic avenues for cardiovascular disease (CVD).

Keywords:
AtherosclerosisImmune cellsInflammationMultiple organs

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Area of Science:

  • Cardiovascular Science
  • Immunology
  • Pathology

Background:

  • Atherosclerosis is a chronic inflammatory vascular disease.
  • It involves lipoprotein deposition, immune cell accumulation, and fibrous tissue formation.
  • This disease affects nearly all organs, impacting their functions.

Purpose of the Study:

  • To review how atherosclerosis interferes with organ functions.
  • To explore the role of immune disturbances in atherosclerosis-related multi-organ dysfunction.
  • To highlight potential new therapeutic strategies for cardiovascular disease (CVD).

Main Methods:

  • Literature review of atherosclerosis and its systemic effects.
  • Analysis of common pathways linking atherosclerosis to organ dysfunction.
  • Examination of immune system dysregulation in atherosclerosis.

Main Results:

  • Atherosclerosis impacts organ function through local vascular changes, cholesterol pathologies, and immune responses.
  • Immune system disturbances in atherosclerosis contribute to dysfunction in multiple tissues.
  • The disease's microenvironment plays a critical role in multi-organ pathology.

Conclusions:

  • Atherosclerosis is a systemic disease with widespread organ implications.
  • Understanding atherosclerosis-induced immune dysregulation is key to addressing multi-organ pathology.
  • This knowledge can lead to novel therapeutic opportunities for CVD.