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REM sleep behavior disorder as a complex condition with heterogeneous underlying disorders: clinical management and
1Minnesota Regional Sleep Disorders Center and Departments of Psychiatry, Hennepin County Medical Center and University of Minnesota Medical School, Minneapolis, MN, USA. schen010@umn.edu.
Sleep & Breathing = Schlaf & Atmung
|March 3, 2022
Summary
REM sleep behavior disorder (RBD) is a complex condition with diverse causes, including neurodegenerative diseases. Early diagnosis and management are crucial for patient outcomes and future research.
Area of Science:
- Neurology
- Sleep Medicine
- Neuroscience
Background:
- REM sleep behavior disorder (RBD) is a complex condition with heterogeneous underlying disorders.
- RBD presents with REM-without-atonia (RWA) on video-polysomnography.
- It can manifest across the lifespan, either as an idiopathic condition (iRBD) or associated with other disorders.
Purpose of the Study:
- To review the heterogeneous underlying disorders associated with RBD.
- To examine clinical management issues and prognostic implications of RBD.
Main Methods:
- Literature search of PubMed.
- Inclusion of content from the first textbook of RBD (2018).
Main Results:
- RBD is linked to narcolepsy, alpha-synuclein disorders (Parkinson's disease, dementia with Lewy bodies), paraneoplastic syndromes, autoimmune disorders, CNS lesions, psychiatric conditions, and medication side effects.
- Idiopathic RBD (iRBD) often evolves into Parkinson's disease or dementia with Lewy bodies in older adults, highlighting prognostic significance.
- RBD typically responds to melatonin and/or clonazepam; further research is needed on its links with narcolepsy and obstructive sleep apnea (OSA).
Conclusions:
- RBD research and clinical practice involve multiple disciplines, including neurology, pulmonary, psychiatry, and sleep medicine.
- Understanding the diverse associations and prognostic implications of RBD is essential for comprehensive patient care.
- Recognizing RBD mimics is critical for accurate diagnosis and effective management.
Keywords:
Antidepressant medicationsDream-enacting behaviorsNarcolepsyNeurodegenerative disordersObstructive sleep apneaParasomnia overlap disorderPost-traumatic stress disorderRBDREM sleep behavior disorderREM-without-atoniaMore Related Videos
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