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The role of ATG16L2 in autophagy and disease

Laurence Don Wai Luu1, Nadeem O Kaakoush2, Natalia Castaño-Rodríguez1

  • 1School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, New South Wales, Australia.

Autophagy
|March 3, 2022
PubMed

Insights

Autophagy related 16 like 2 (ATG16L2) is an understudied protein linked to various diseases. This review explores its potential role in modulating autophagy and its implications in pathogenesis.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Disease Pathogenesis

Background:

  • Macroautophagy/autophagy is vital for cellular homeostasis and defense.
  • ATG16L2 is an autophagy-related protein, a paralog of ATG16L1, implicated in various diseases.
  • While ATG16L1 is well-studied, ATG16L2 remains largely uncharacterized.

Purpose of the Study:

  • To review current literature on ATG16L2.
  • To explore the potential function of ATG16L2 in autophagy.
  • To discuss the implications of ATG16L2 in disease pathogenesis.

Main Methods:

  • Literature review of studies involving ATG16L2.
  • Analysis of reported associations between ATG16L2 and diseases.
  • Collating evidence for ATG16L2's role in autophagy.

Main Results:

  • ATG16L2 overexpression is reported in colorectal, gastric, and prostate cancers.
  • Altered ATG16L2 methylation is linked to lung cancer and leukemia treatment response.
  • ATG16L2 polymorphisms are associated with inflammatory bowel diseases and neurodegenerative disorders.

Conclusions:

  • ATG16L2 is implicated in diverse human diseases.
  • Evidence suggests ATG16L2 may be a novel modulator of autophagy.
  • Further research is needed to elucidate ATG16L2's precise function in autophagy and disease.
Keywords:
ATG16L1ATG16L2autophagycancermacroautophagyxenophagy

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