Related Experiment Video
Updated: Oct 1, 2025

Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
Intraoperative Anaphylaxis to the Bovine Flowable Gelatin Matrix: A Report of 2 Cases
Josephine R Coury1, Kira F Skaggs1, Gerard F Marciano1
1Department of Pediatric Orthopedic Surgery, New York-Presbyterian/Columbia University Irving Medical Center, New York, New York.
Case:
We present 2 cases of life-threatening intraoperative anaphylaxis to the bovine flowable gelatin matrix during pediatric spinal deformity surgery for kyphoscoliosis. Both patients had no known bovine or gelatin allergies. Anaphylaxis occurred shortly after pressurized injection into the first cannulated pedicle tract and was successfully treated with epinephrine, diphenhydramine, and methylprednisolone infusion. The allergic reaction was confirmed with tryptase levels and serum-specific immunoglobulin E for beef, pork, bovine collagen, and porcine collagen.
Conclusion:
In patients with beef, pork, or gelatin intolerance, a significant atopic history or childhood vaccine reaction, preoperative allergy consultation, and testing should be performed to prevent this life-threatening complication.
Related Concept Videos
Allergic Reactions
Local Anesthetics: Adverse Effects
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Allergic Drug Reactions
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...

