Related Experiment Video
Updated: Oct 1, 2025

Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing
Published on: July 7, 2020
Overview of polymyxin resistance in Enterobacteriaceae
Kesia Esther da Silva1,2, Luana Rossato1, Andressa Ferraz Leite1
1Universidade Federal da Grande Dourados, Laboratório de Pesquisa em Ciências da Saúde, Dourados, MS, Brasil.
Abstract:
Polymyxin antibiotics are disfavored owing to their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic development pipeline, together with the increasing global prevalence of infections caused by multidrug-resistant (MDR) gram-negative bacteria, have renewed clinical interest in these polypeptide antibiotics. This review highlights the current information regarding the mechanisms of resistance to polymyxins and their molecular epidemiology. Knowledge of the resistance mechanisms and epidemiology of these pathogens is critical for the development of novel antibacterial agents and rapid treatment choices.
Related Concept Videos
Development of Antibiotic Resistance
Antibiotic Selection
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Gene Regulation in Microbial Communities: Quorum Sensing
Combined Effects of Drugs: Synergism
Such synergistic combinations...

