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Updated: Oct 1, 2025
Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue
Published on: July 17, 2018
The composition, function, and regulation of adipose stem and progenitor cells
Xiyan Liao1, Haiyan Zhou2, Tuo Deng3
1National Clinical Research Center for Metabolic Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China; Key Laboratory of Diabetes Immunology, Ministry of Education, and Metabolic Syndrome Research Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China.
Adipose stem and progenitor cells (ASPCs) exhibit molecular diversity across fat depots. Understanding these subtypes offers potential therapeutic targets for metabolic disorders through adaptive adipose growth.
Area of Science:
- Metabolic research
- Cell biology
- Adipose tissue biology
Background:
- White adipose tissue (WAT) is a key regulator of energy metabolism.
- Adipose stem and progenitor cells (ASPCs) are crucial for WAT function and adipocyte generation.
- The heterogeneity and diversity of ASPCs remain largely undefined.
Purpose of the Study:
- To review current knowledge on ASPC populations.
- To explore ASPC markers, functions, and regulatory mechanisms.
- To highlight the therapeutic potential of targeting ASPCs for metabolic disorders.
Main Methods:
- Review of existing literature on ASPC research.
- Analysis of single-cell RNA sequencing (scRNA-seq) data from murine and human adipose tissues.
- Synthesis of information on molecular heterogeneity and functional diversity.
Main Results:
- scRNA-seq has revealed distinct ASPC subtypes in various fat depots.
- Identification of specific markers and functions for different ASPC populations.
- Understanding of regulatory mechanisms governing ASPC behavior.
Conclusions:
- ASPC populations are more complex than previously thought.
- Targeting specific ASPC subtypes may offer novel therapeutic strategies.
- Promoting adaptive hyperplastic adipose growth via ASPC modulation could treat metabolic diseases.
