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Updated: Oct 1, 2025

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
Published on: August 18, 2017
On-the-fly analysis of chloride and bromide in drug samples using NMR spectroscopy
Vincent Guillou1, Torsten Schönberger1
1Federal Criminal Police Office, Forensic Science Institute, Äppelallee 45, 65203 Wiesbaden, Germany.
Abstract:
A look over the horizon shows that the excellent principle of quantitative NMR spectroscopy can also be applied to unreceptive quadrupolar nuclei. Drugs are often present as HCl or HBr salts. The nuclei 35Cl and 79Br can also be excellently determined qualitatively and quantitatively by NMR when they are present in ionic form. External calibration is used, which has proven to be extremely stable. The validation parameters of the methods already accredited to ISO 17025 are given. The methods proved to be extremely robust. The analyses can be performed practically on-the-fly. This means that the analysis can be carried out within a few minutes in addition to the actual quantitative determination of the organic components without further sample preparation.
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