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Shape memory micro-anchors with magnetic guidance for precision micro-vascular deployment.

Zhihua Li1, Zijian Chen2, Yanan Gao1

  • 1Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China.

Biomaterials
|March 3, 2022
PubMed
Summary

A new biodegradable magnetic micro-anchor (SM²A) offers stable endovascular localization for medical micro-devices. This shape-memory device enables precise anchoring in blood vessels for targeted therapies.

Keywords:
EmbolotherapyHyperthermiaMagnetic guidanceMicro-deviceShape memory polymer

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Area of Science:

  • Biomaterials Engineering
  • Nanotechnology
  • Vascular Interventions

Background:

  • Transcatheter micro-devices offer therapeutic potential but lack stable anchoring in vascularized tissues.
  • Current strategies are insufficient for precise localization and in-situ action of endovascular tools.
  • Need for advanced anchoring solutions for minimally invasive treatments.

Purpose of the Study:

  • To develop a shape memory functionalized biodegradable magnetic micro-anchor (SM²A) for stable endovascular localization.
  • To achieve magnetic-guided localization through precisely controlled shape transformation.
  • To enable precision deployment and in-situ action of diagnostic or therapeutic agents.

Main Methods:

  • Fabrication of SM²A using anisotropic polylactide-based microparticles embedded with superparamagnetic Fe₃O₄ nanoparticles.
  • Utilized thermally activated, tunable shape recovery modes within a body-friendly temperature range.
  • Tested anchoring efficacy in decellularized liver organ and rabbit ear embolization models.

Main Results:

  • Demonstrated efficient endovascular anchoring of SM²A at target micro-vessels.
  • Achieved controlled radial expansion of the vessel wall with estimated stresses of 7-26 kPa (contact) and 38-218 kPa (von Mises).
  • Validated magnetic-guided localization through shape transformation.

Conclusions:

  • SM²A provides a stable and controllable anchoring solution for transcatheter medical micro-devices.
  • The biodegradable and magnetic properties facilitate precision deployment and in-situ therapeutic or diagnostic actions.
  • SM²A represents a promising platform for advanced endovascular interventions.