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Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Related Experiment Video

Updated: Oct 1, 2025

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas

Published on: September 5, 2011

Is Amniocentesis after CVS Risky?

Kristen Cagino¹, Stephen T Chasen¹

¹Department of Obstetrics and Gynecology, New York Presbyterian Weill Cornell Medical Center, New York.

American Journal of Perinatology

|March 3, 2022

Summary

This summary is machine-generated.

Women undergoing amniocentesis after chorionic villi sampling (CVS) for placental mosaicism or other issues had similar obstetric outcomes. This reassures patients that a second invasive procedure does not increase adverse pregnancy events.

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Last Updated: Oct 1, 2025

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas

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Published on: September 5, 2011

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The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

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Published on: August 2, 2017

Area of Science:

Maternal-Fetal Medicine
Prenatal Diagnostics
Reproductive Genetics

Background:

Approximately 2% of women undergoing chorionic villi sampling (CVS) require a subsequent amniocentesis.
Reasons for a second procedure include placental mosaicism, sampling errors, or laboratory issues.
The obstetric outcomes of women undergoing both CVS and amniocentesis are not well-established.

Purpose of the Study:

To compare obstetric outcomes in women who underwent both CVS and amniocentesis versus those who underwent CVS alone.
To assess the safety and impact of a second invasive procedure on pregnancy outcomes.

Main Methods:

Retrospective case-control study (2010-2020) of singleton pregnancies.
Compared 66 women who had CVS followed by amniocentesis with 132 controls who had CVS alone.
Matched for maternal age and year of pregnancy; excluded early pregnancy loss and terminations.

Main Results:

No significant differences in pregnancy loss or stillbirth between the two groups.
Women undergoing both procedures delivered at similar gestational ages and birthweights.
Amniocentesis was performed for placental mosaicism (44%), sampling/lab issues (33%), or further testing (23%).

Conclusions:

Women requiring amniocentesis after CVS can be reassured about adverse outcomes.
The study suggests that a second invasive procedure does not increase risks.
Larger studies may be needed to detect rare adverse event differences.