Using a "systems therapeutic for physiological renormalization" approach to vaccine development. Covid-19 as an...

Area of Science:

• Immunology
• Vaccinology
• Virology

Background:

• Current COVID-19 vaccines have limitations in preventing viral spread and the emergence of more transmissible and virulent variants.
• Viral replication during widespread infections facilitates mutations and recombination, leading to enhanced pathogenicity.

Purpose of the Study:

• To propose a novel vaccine and dosing strategy to overcome the limitations of current COVID-19 vaccines.
• To induce "physiological renormalization" through immune system mimicry of natural infection.

Main Methods:

• A "systems therapeutic" vaccine approach is suggested.
• The strategy aims to induce specific immune responses in respiratory tracts and sera.
• Mimicry of the host's response to natural infectious agents is a key component.

Main Results:

• The proposed strategy is expected to enhance innate and adaptive immune system responses.
• It aims to achieve a state of "physiological renormalization" within the host.
• This approach seeks to improve control over viral spread and variant formation.

Conclusions:

• A "systems therapeutic" vaccine strategy offers a potential new direction for controlling COVID-19.
• Inducing immune mimicry of natural infection could lead to more robust and effective immunity.
• This approach may help mitigate the impact of viral mutations and enhance vaccine efficacy.