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Updated: Oct 1, 2025

Immunohistochemical Analysis in the Rat Central Nervous System and Peripheral Lymph Node Tissue Sections
Published on: November 14, 2016
Primary central nervous system lymphoma high incidence and poor survival in Finnish population-based analysis
Inka Puhakka1, Hanne Kuitunen2, Pekka Jäkälä3,4
1Department of Neurology, Kuopio University Hospital, PL 100, 70029, Kuopio, KYS, Finland. inka.puhakka@kuh.fi.
Background:
We report here the first population-based incidence rates and prognosis of primary central nervous system lymphoma (PCNSL) in Finland.
Methods:
Finnish Cancer Registry data by histological diagnosis and tumor location (2007-2017) for cases with diffuse large B-cell lymphoma.
Results:
During 2007-2017, 392 new cases of PCNSL were reported (195 males, 197 females). The average age-adjusted incidence was 0.68/100,000 person-years. Incidence for males was 0.74/100,000 and for females 0.63/100,000, respectively. The incidence was highest, 2.93/100,000, among people aged 75-79 years. Concerning all cases in 2007-2017 the 2-year age-adjusted relative survival rate was 33% and the corresponding 5-year survival rate was 26%. Among patients under the age of 70, the age-adjusted 5-year relative survival rate increased from 36% in 2007-2012 to 43% for 2013-2017. Among patients aged 70+ the corresponding survival rates were poor, 7 and 9%.
Conclusions:
PCNSL incidence in Finland is among the highest reported in the world. The annual increase in incidence was 2.4%. The prognosis is still dismal, especially in elderly patients.
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