Antidepressant Fluoxetine Does Not Appear to Interfere With Key Translational Parameters in the Rat Adjuvant-induced
Dasa Seveljevic-Jaran1,2, Otto Kalliokoski2, Klas S P Abelson2
1Toxicology and Laboratory Animal Science Department, Fidelta Ltd., Zagreb, Croatia; dasa.seveljevicjaran@fidelta.eu.
Background/Aim:
This study aimed to investigate the analgesic effects of fluoxetine on Lewis rats of both sexes in the adjuvant-induced arthritis (AIA) rat model. In humans, chronic pain syndromes typical of rheumatoid arthritis (RA) co-exist with depression which is often treated with fluoxetine antidepressant known to have antinociceptive effects.
Materials And Methods:
The experiment was terminated on day 26, after seven days of oral treatment (days 19-25) with fluoxetine and indomethacin. The effects of treatments were assessed on the final day of the study through measuring body weight, serum concentrations of a1-acid glycoprotein, visual arthritis assessment and post mortem histopathology assessment.
Results:
Statistically significant difference was determined in the body weight of male subjects, with indomethacin-treated animals putting on significantly more weight than the vehicle and fluoxetine-treated counterparts. No differences were found between the different treatment groups in other study assessments.
Conclusion:
The present study did not provide support for analgesic effects of fluoxetine aimed at reducing the severity of the AIA model.
