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Updated: Oct 1, 2025

Generation of Oligodendrocytes and Oligodendrocyte-Conditioned Medium for Co-Culture Experiments
Published on: February 9, 2020
Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling
Yan Xiao1, Luigi Petrucco2,3, Laura J Hoodless4
1Institute of Neuronal Cell Biology, Technical University of Munich, Munich, Germany.
Abstract:
Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell population. The zebrafish optic tectum contains OPCs in regions devoid of myelin. Elimination of these OPCs impaired precise control of retinal ganglion cell axon arbor size during formation and maturation of retinotectal connectivity and degraded functional processing of visual stimuli. Therefore, OPCs fine-tune neural circuits independently of their canonical role to make myelin.
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