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Updated: Oct 1, 2025

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Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
Published on: June 18, 2021
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Pseudosubarachnoid hemorrhage
Adeel Shakil Zubair1, Michele Johnson2, Emily Jean Gilmore1
1Department of Neurology, Yale School of Medicine, New Haven, Connecticut, United States.
Surgical Neurology International
|March 4, 2022
Summary
Pseudosubarachnoid hemorrhage, a false finding on imaging, can occur in patients with severe brain injury or high carbon dioxide levels. This highlights the importance of correlating imaging with clinical context after cardiac arrest.
Area of Science:
- Neurology
- Radiology
- Emergency Medicine
Background:
- Post-cardiac arrest imaging is crucial for medical decision-making and family communication.
- Accurate interpretation of neuroimaging is vital in critical care settings.
Observation:
- A patient experiencing in-hospital cardiac arrest underwent imaging revealing diffuse bilateral subarachnoid hemorrhage.
- Subsequent advanced neuroimaging (MRI) and autopsy findings did not confirm the initial hemorrhage report.
Findings:
- The initial imaging finding was determined to be a pseudosubarachnoid hemorrhage.
- This false positive finding is associated with diffuse cerebral edema, often linked to hypercarbia or severe acute brain injury.
Implications:
- Clinical correlation is essential when interpreting neuroimaging in post-cardiac arrest patients.
- Understanding pseudosubarachnoid hemorrhage can prevent misdiagnosis and guide appropriate patient management.
- This case underscores the need for careful evaluation of imaging findings in the context of severe neurological injury.
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