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A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
Published on: May 16, 2020
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Sibutramine-Induced Nonischemic Cardiomyopathy.
Meet S Shah1, Zeel K Patel1, Ronak Bharucha2
1Internal Medicine, Rutgers University New Jersey Medical School, Newark, USA.
Cureus
|March 4, 2022
Summary
Sibutramine, an anti-obesity drug, can cause severe heart problems like nonischemic cardiomyopathy. This case report details a young patient
Area of Science:
- Cardiology
- Pharmacology
Background:
- Obesity pharmacotherapy development is driven by rising global obesity rates and associated comorbidities.
- Sibutramine hydrochloride monohydrate, a serotonin-norepinephrine reuptake inhibitor, was used for weight loss but withdrawn due to cardiovascular risks.
Observation:
- A 19-year-old male with no prior medical history experienced cardiac arrest and was diagnosed with acute systolic heart failure.
- Cardiac catheterization showed patent coronary arteries, while echocardiography revealed a severely reduced ejection fraction (15%-20%).
- The patient presented with pulseless ventricular fibrillation and non-sustained ventricular tachycardia.
Findings:
- The patient was diagnosed with sibutramine-induced nonischemic cardiomyopathy.
- Standard medical management for acute systolic heart failure was initiated.
- An implantable cardioverter-defibrillator (ICD) was placed due to recurrent ventricular tachycardia.
Implications:
- This case highlights the potential for sibutramine to cause severe, nonischemic cardiomyopathy, even in young individuals.
- It underscores the importance of careful patient selection and monitoring for cardiovascular events associated with anti-obesity medications.
- The management involved a multidisciplinary approach including cardiac care and device implantation.
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