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Updated: Oct 1, 2025
Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
Published on: May 11, 2016
Clinicopathological and therapeutic analysis of primary breast squamous cell carcinoma
Zhiying Chen1, Ning An1, Lei Zhang1
1Department of Radiation Oncology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Background:
Primary squamous cell carcinoma (PSCC) of the breast is a rare type of breast cancer that exhibits unique biological behavior. The pathogenesis, clinical manifestations, and effective treatment methods of this breast cancer are still unclear.
Methods:
We collected all breast PSCC patients who were treated in our hospital from June 2010 to December 2018 for retrospective analysis. The clinical, pathological, treatment, and prognostic characteristics of all patients were described and compared to past breast PSCC data, to provide advice on the diagnosis and treatment for breast PSCC.
Results:
We identified 35 patients with breast PSCC treated at our hospital during this period. Preoperative ultrasound showed cystic hypoechoic nodules and abundant blood flow signals in 83.33% of the cases. Postoperative pathology showed that the average diameter of the breast mass was 27.51 mm, and 34.29% of the patients had poor differentiation. A total of 33 patients had negative expression of estrogen receptor (ER) and progesterone receptor (PR), and 32 patients had no overexpression of human epidermal growth factor receptor 2 (HER2). The average follow-up time was 36.29 months. There were 3 cases of local recurrence, 2 cases of distant metastasis, and 1 case of natural death.
Conclusions:
Breast PSCC has a special biological behavior. Surgery is the main treatment, platinum-containing chemotherapy may be more effective for breast PSCC. Radiotherapy can reduce local recurrence, but the scope and dose of radiotherapy need to be further confirmed.
