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Plasma proteomics data from hibernating and active Scandinavian brown bears.
Anne Mette Frøbert1, Simon Gregersen1, Malene Brohus1
1Department of Chemistry and Bioscience, Faculty of Engineering and Science, Aalborg University, Fredrik Bajers Vej 7H, Aalborg 9220, Denmark.
Data in Brief
|March 4, 2022
Summary
Hibernating brown bears offer insights into human health. Their plasma proteomics reveal adaptations to prolonged inactivity and obesity, suggesting potential therapeutic targets for human metabolic disorders.
Area of Science:
- Proteomics
- Comparative Physiology
- Mammalian Hibernation
Background:
- Brown bears hibernate for extended periods, remaining obese and inactive without apparent ill effects.
- This unique physiological state makes hibernating bears a valuable translational model for human metabolic diseases.
Purpose of the Study:
- To present mass-spectrometry based plasma proteomics data from hibernating and active Scandinavian brown bears.
- To identify proteins involved in hibernation adaptations and potential therapeutic targets.
Main Methods:
- Plasma samples from 14 brown bears (hibernating and active states) were analyzed.
- Proteins were processed, digested, and analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
- Data analysis involved MaxQuant software against a brown bear protein database.
Main Results:
- Provided raw proteomics data, identified proteins, and applied databases.
- Enables identification of differentially expressed proteins between hibernation and active states.
- Highlights proteins potentially crucial for hibernation physiology.
Conclusions:
- Hibernating bears exhibit unique plasma proteomic profiles.
- These profiles may offer novel therapeutic targets for human conditions like obesity and inactivity-related complications.
- The study provides a foundation for further research into bear hibernation adaptations.
