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A Tetragenococcus halophilus human gut isolate.
Cheick Oumar Guindo1,2, Madjid Morsli1,2, Sara Bellali1
1IHU Méditerranée Infection, Marseille, France.
Current Research in Microbial Sciences
|March 4, 2022
Summary
Tetragenococcus halophilus, a salt-loving bacterium, was found in human feces for the first time. This discovery expands our understanding of the human gut microbiome and suggests potential health benefits of this halophilic microorganism.
Area of Science:
- Microbiology
- Human Microbiome Research
- Gastroenterology
Background:
- Tetragenococcus halophilus is a known halophilic lactic acid bacterium found in salty foods.
- This bacterium has been associated with potential beneficial effects on human health.
Purpose of the Study:
- To investigate the presence of Tetragenococcus halophilus in human samples.
- To isolate and culture T. halophilus from human gastrointestinal tract.
- To characterize the antibiotic susceptibility profile of the isolated strain.
Main Methods:
- Polyphasic approach including scanning electron microscopy, molecular biology, and microbial culture.
- Minimum Inhibitory Concentration (MIC) assessment using E-test strips.
- Whole genome sequencing and in-silico profiling.
Main Results:
- Tetragenococcus halophilus was successfully detected, isolated, and cultured from human feces samples for the first time.
- The study determined the MIC values for various antibiotics against the isolated T. halophilus strain CSURQ6002.
- In-silico profiling confirmed genomic data.
Conclusions:
- Tetragenococcus halophilus is a newly identified component of the human digestive microbiota.
- The presence of T. halophilus in the human gut warrants further investigation into its role in human health.
- This finding enriches the understanding of halophilic microorganisms in the human gastrointestinal tract.
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