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Updated: Oct 1, 2025

Capillary Force Lithography for Cardiac Tissue Engineering
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Nanotechnology for cardiovascular diseases.

Qinqin Hu1,2, Zheyan Fang1, Junbo Ge1,2

  • 1Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Shanghai Xuhui District Central Hospital & Zhongshan-xuhui Hospital, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Innovation (Cambridge (Mass.))
|March 4, 2022
PubMed
Summary

Nanotechnology enhances the diagnosis and treatment of coronary artery diseases (CADs). Nanomaterials improve biosensors, imaging, drug delivery, and offer direct therapeutic effects for atherosclerosis.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cardiovascular Medicine

Background:

  • Coronary artery diseases (CADs) are leading causes of mortality globally.
  • Current CAD diagnosis and treatment methods have limitations.
  • Nanotechnology offers promising solutions for CAD management.

Purpose of the Study:

  • To review recent advances in nanotechnology for CAD diagnosis.
  • To discuss nanomaterials as drug carriers for CAD therapy.
  • To explore nanomaterials as direct therapeutic agents for atherosclerosis.

Main Methods:

  • Elucidation of nanotechnology in CAD diagnosis (biosensors, molecular imaging).
  • Discussion of various nanomaterials (liposomes, polymers, inorganic, natural, biomimetic nanoparticles) as drug carriers.
Keywords:
cardiovascular diseasesdrug delivery systemmolecular imagingmultimodal imagingnanotechnology

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  • Exploration of intrinsic therapeutic properties of nanomaterials (antioxidative, anti-inflammatory, photoelectric/photothermal).

    • Main Results:

    • Nanomaterials significantly increase sensitivity and specificity in CAD biomarker detection and molecular imaging.
    • Engineered nanomaterials effectively target pathological sites for drug delivery.
    • Certain nanomaterials exhibit direct therapeutic effects against atherosclerosis.

    Conclusions:

    • Nanotechnology holds significant potential for improving CAD diagnosis and treatment.
    • Continued research in nanotechnology is crucial for clinical translation in cardiovascular medicine.
    • Nanoscale technologies will expand diagnostic and therapeutic horizons for CAD.