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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
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Upregulated miR-328-3p and its high risk in atrial fibrillation: A systematic review and meta-analysis with

Haitao Huang1, Hao Chen2, Xiao Liang2

  • 1Department of Cardiology, the Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.

Medicine
|March 4, 2022
PubMed
Abstract

Insights

MicroRNA-328-3p levels are significantly elevated in patients with atrial fibrillation (AF). This finding suggests miR-328-3p may serve as a valuable biomarker for AF diagnosis and risk assessment.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Biomarker Discovery

Background:

  • Conflicting reports exist regarding miR-328-3p levels in atrial fibrillation (AF).
  • Existing studies show inconsistent findings on whether miR-328-3p is increased, decreased, or unchanged in AF patients.
  • Clarifying the role of miR-328-3p in AF is crucial for understanding its diagnostic potential.

Purpose of the Study:

  • To systematically assess the association between miR-328-3p levels and atrial fibrillation (AF).
  • To resolve inconsistencies in previous research regarding miR-328-3p expression in AF.
  • To evaluate miR-328-3p as a potential biomarker for AF.

Main Methods:

  • A comprehensive literature search was conducted across PubMed, EMBASE, Scopus, Web of Science, and ProQuest up to February 1, 2021.
  • Standardized mean differences (SMD) with 95% confidence intervals (CI) were calculated for meta-analysis.
  • Sensitivity and trim-fill analyses were performed to ensure the robustness and credibility of the findings.

Main Results:

  • Twelve studies involving meta-analysis revealed significantly higher miR-328-3p levels in AF patients compared to controls (SMD = 0.69, P = .022).
  • Adjusted analysis confirmed elevated miR-328-3p levels in AF (SMD = 0.82, P = .007).
  • Subgroup analyses indicated higher miR-328-3p expression in larger patient cohorts (n ≥ 30), those with comorbidities, earlier publications, and Asian populations.

Conclusions:

  • Elevated miR-328-3p levels are significantly associated with an increased risk of atrial fibrillation (AF).
  • MiR-328-3p demonstrates a significant role in AF pathogenesis and diagnosis.
  • MiR-328-3p holds promise as a potential and useful biomarker for identifying AF.

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