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[Lysosome activity in mice during rejection of a heterotopic heart implant]
Allotransplantation of the heart from newborn mice C57B1/6 into the pinna of adult CBA mice on the 3rd day after operation led to increased acid phosphatase activity and activation of the Golgi apparatus. Numerous lysosomes whose membrane became disrupted on the 7th-9th day from the time of implantation appeared later. At the same time histochemical study demonstrated local loss of acid phosphatase activity and a diffuse staining (brown) of the cytoplasm. No destruction of the lysosome membranes or release of the enzymes into the cytoplasm occurred in case of heart isografts (CBA-GBA).
Allotransplantation of the heart from newborn mice C57B1/6 into the pinna of adult CBA mice on the 3rd day after operation led to increased acid phosphatase activity and activation of the Golgi apparatus. Numerous lysosomes whose membrane became disrupted on the 7th-9th day from the time of implantation appeared later. At the same time histochemical study demonstrated local loss of acid phosphatase activity and a diffuse staining (brown) of the cytoplasm. No destruction of the lysosome membranes or release of the enzymes into the cytoplasm occurred in case of heart isografts (CBA-GBA).