Related Experiment Video
Updated: Oct 1, 2025

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
Published on: May 21, 2018
Inflammasome and gasdermin signaling in neutrophils
See Jie Yow1,2, Hui Wen Yeap1,2, Kaiwen W Chen1,2
1Immunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Abstract:
Inflammasomes and gasdermins mount potent host defense pathways against invading microbial pathogens, however, dysregulation in these pathways can drive a variety of inflammatory disorders. Neutrophils, historically regarded as effector phagocytes that drive host defense via microbial killing, are now emerging as critical drivers of immunity in vivo. Here, we summarize, the latest advancement in inflammasome, gasdermin, and cell death signaling in neutrophils. We discuss the mechanisms by which neutrophils resist caspase-1-dependent pyroptosis, the lytic function of gasdermin D and E during NETosis and Yersinia infection, and the contribution of neutrophil inflammasomes to inflammatory disorders.
Related Concept Videos
Inflammation
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...
IP3/DAG Signaling Pathway
The Extrinsic Apoptotic Pathway
Amplifying Signals via Enzymatic Cascade
Intracellular Signaling Affects Focal Adhesions
Some...

