Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation.

Y Kitamura, S Go, K Hatanaka

    Blood
    |August 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Direct observation of the superallowed α-decay of <sup>104</sup>Te.

    Nature·2026
    Same author

    Demonstration of nuclear gamma-ray polarimetry based on a multi-layer CdTe Compton camera.

    Scientific reports·2024
    Same author

    Hepatobiliary and pancreatic: Tiny pigmented intra-hepatic ducts stones as the cause of jaundice and liver failure.

    Journal of gastroenterology and hepatology·2023
    Same author

    β-Delayed One and Two Neutron Emission Probabilities Southeast of ^{132}Sn and the Odd-Even Systematics in r-Process Nuclide Abundances.

    Physical review letters·2022
    Same author

    Gastrointestinal: Rare malignant biliary stricture with rapid progression.

    Journal of gastroenterology and hepatology·2022
    Same author

    Tumor-to-tumor metastasis: lung cancer within a thymoma.

    General thoracic and cardiovascular surgery·2020
    Same journal

    Fibrocytes drive JAK2V617F-mutated myelofibrosis: pitavastatin reverses marrow fibrosis and anemia.

    Blood·2026
    Same journal

    Identifying steroid-refractory aGVHD before it happens.

    Blood·2026
    Same journal

    ELISA-negative HIT: antibody recognition and relevance.

    Blood·2026
    Same journal

    EBV and immunodeficiency: the odd couple drawn to the brain.

    Blood·2026
    Same journal

    A bone to pick with ferric carboxymaltose.

    Blood·2026
    Same journal

    A step toward streamlining HIT diagnosis.

    Blood·2026
    See all related articles

    Genetically anemic W/Wv mice have abnormal mast cell production. Bone marrow transplants from normal mice restored mast cell levels, indicating W/Wv mice are valuable for studying mast cell origins and functions.

    Area of Science:

    • Immunology
    • Hematology
    • Genetics

    Background:

    • Mast cells are crucial immune cells found in various tissues.
    • The W/Wv mouse model exhibits a genetic anemia and a deficiency in mast cells.
    • Understanding mast cell production is vital for immunology and disease research.

    Purpose of the Study:

    • To investigate the abnormal production of mast cells in W/Wv mice.
    • To determine if bone marrow transplantation can restore mast cell populations in W/Wv mice.
    • To establish the W/Wv mouse as a model for mast cell research.

    Main Methods:

    • Evaluation of mast cell numbers in the skin and other tissues of W/Wv and control (+/+) mice.
    • Comparison of mast cell counts before and after bone marrow transplantation.

    Related Experiment Videos

  • Analysis of mast cell distribution in various organs.

    • Main Results:

    • W/Wv mice showed significantly fewer mast cells (<1% in skin) compared to +/+ mice.
    • No mast cells were detected in most tissues of untreated W/Wv mice.
    • Bone marrow transplantation from +/+ mice restored mast cell numbers in W/Wv mice across multiple tissues.

    Conclusions:

    • The W/Wv mouse genotype is associated with a severe defect in mast cell production.
    • Bone marrow-derived cells are essential for mast cell reconstitution.
    • The W/Wv mouse is a suitable model for studying the physiological roles and origin of mast cells.