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COVID-19 Positive Cohort Undergoing Cardiac Surgery: A Possible Un(3H)oly Trinity of

Rohan Magoon1, Ramesh Kashav1, Jes Jose2

  • 1Department of Cardiac Anaesthesia, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital, Baba Kharak Singh Marg, New Delhi, India.

Brazilian Journal of Cardiovascular Surgery
|March 4, 2022
PubMed

Insights

This study proposes a 3H trilogy (Hypoxia-Hemolysis-Hyperinflammation) to explain how COVID-19 impacts cardiac surgery patients. Understanding this link aids perioperative management for better patient outcomes.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Coronavirus disease (COVID-19) positivity presents unique challenges in cardiac surgery patients.
  • The precise mechanisms linking COVID-19 infection to adverse cardiac surgical outcomes remain under investigation.

Purpose of the Study:

  • To elucidate the pathophysiological mechanisms connecting cardiopulmonary bypass and COVID-19 infection in cardiac surgery.
  • To propose a framework for improved perioperative management strategies.

Main Methods:

  • Conceptual framework development based on existing literature.
  • Integration of known physiological effects of cardiopulmonary bypass and COVID-19.

Main Results:

  • Introduction of the 3H trilogy: Hypoxia, Hemolysis, and Hyperinflammation as key interacting factors.
  • Hypothesized interplay between cardiopulmonary bypass-induced stress and COVID-19 pathophysiology.

Conclusions:

  • The 3H trilogy offers a novel perspective on COVID-19's impact on cardiac surgery.
  • A pathophysiology-driven approach can enhance perioperative care for these complex patients.

Keywords:
Cardiopulmonary BypassComprehensionCovid-19HemolysisHypoxiaSARS-CoV-2

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