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A platinum-based fluorescent "turn on" sensor to decipher the reduction of platinum(IV) prodrugs
Houzong Yao1,2, Guangyu Zhu1,2
1Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong SAR 999077, People's Republic of China. guangzhu@cityu.edu.hk.
Abstract:
We report a strategy to use a fluorescence "turn on" sensor to quantify the reduction of platinum(IV) prodrugs in a real-time mode by simply and conveniently monitoring the fluorescence intensity. Proteins with high molecular weights, especially those between 10 and 100 kDa, contribute more to the reduction of the platinum(IV) complex in cell extracts.
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