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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Polygenic Traits01:18

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When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
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B Cell Activation and Differentiation01:24

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Related Experiment Video

Updated: Oct 1, 2025

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
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B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS.

Sophia S Wang1, Claire M Vajdic2, Martha S Linet3

  • 1Division of Health Analytics, Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Monrovia, California.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
|March 4, 2022
PubMed
Summary
This summary is machine-generated.

Polygenic risk scores (PRS) for diffuse large B-cell lymphoma (DLBCL) show increased risk, especially when combined with autoimmune conditions. This highlights potential for targeted screening in at-risk populations.

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Area of Science:

  • Genetics
  • Immunology
  • Oncology

Background:

  • Previous research explored immune gene variants and autoimmune conditions' impact on non-Hodgkin lymphoma (NHL) risk.
  • This study extends prior work by utilizing subtype-specific polygenic risk scores (PRS) for NHL.

Purpose of the Study:

  • To evaluate the joint associations between autoimmune conditions and PRS for specific NHL subtypes.
  • To investigate the risk of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, and marginal zone lymphoma (MZL) in relation to PRS and autoimmune status.

Main Methods:

  • A pooled analysis of NHL cases and controls from 14 International Lymphoma Epidemiology (InterLymph) studies was conducted.
  • Unconditional logistic regression was used to assess associations between autoimmune conditions, PRS tertiles, and NHL risk.

Main Results:

  • A significant positive association was found between DLBCL PRS and DLBCL risk.
  • Individuals with autoimmune conditions and higher DLBCL PRS tertiles exhibited substantially increased DLBCL risk.
  • No significant joint associations or interactions were observed for follicular lymphoma or MZL.

Conclusions:

  • Current subtype-specific PRS may not fully capture shared biological pathways with autoimmune conditions.
  • Targeted genetic screening in individuals with autoimmune conditions could aid in early DLBCL detection and risk identification.