Related Experiment Video
Updated: Oct 1, 2025

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
Depression in patients with epilepsy: screening, diagnosis and management
Abstract:
Depression is the most frequent psychiatric comorbidity in epilepsy patients with a considerable impact on quality of life and a poor prognosis for the response to pharmacological and surgical treatments. The relationship between depression and epilepsy is bidirectional, involving common pathophysiogenic mechanisms. Despite its frequency and its negative impact on the natural course of the epileptic disease, depression is still underdiagnosed and insufficiently treated in these patients. This may be due to the lack of specific training of neurologists for the detection and management of psychiatric comorbidities, or even to the atypical clinical presentation of depressive symptoms in these patients. The management of depression in epileptics is both pharmacological and non-pharmacological, the main objective being to achieve complete remission of depressive symptoms without reducing seizure threshold. This article aims to describe the epidemiological, clinical and therapeutic aspects of depression in patients with epilepsy, in the light of the most recent data in the literature.
More Related Videos
10:46Author Spotlight: Obtaining High-Quality CSF and Blood Samples for Epilepsy Biomarker Discovery
Published on: September 1, 2023
09:07Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
Published on: August 15, 2017
Related Concept Videos
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Electroconvulsive Therapy
Depression: Overview
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Seizures: Classification
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Psychosis: Goals of Pharmacotherapy