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Assessing Urinary Tract Junction Obstruction Defects by Methylene Blue Dye Injection
Published on: October 12, 2017
The methylene blue test, a risky intervention: A case report
Abstract:
Methylene blue is used to check tubal patency during laparoscopy. We report the case of a 28-year-old patient who presented a blue coloring of the skin, mucous membranes and nails after methylene blue test during laparoscopy for infertility. The oxygen saturation was 82%. The patient was hospitalized for 48 hours in the intensive care unit and spectrophotometric analysis revealed a methemoglobin level of 8.9%, thus confirming the diagnosis of methemoglobinemia. The suites were simple with normalization of the saturation. It is important to know the complications of the injection of methylene blue in order to prevent them and ensure adequate monitoring for the patients.
Insights
Methylene blue dye used in tubal patency tests can cause methemoglobinemia, a condition reducing oxygen transport. Prompt diagnosis and intensive care are crucial for patient recovery.
Area of Science:
- Gynecology
- Toxicology
- Critical Care Medicine
Background:
- Methylene blue is a common diagnostic agent for assessing fallopian tube patency during laparoscopic procedures.
- Infertility investigations frequently involve evaluating tubal patency to identify potential causes.
Observation:
- A 28-year-old patient developed cyanosis (blue skin, mucous membranes, nails) post-laparoscopy with methylene blue.
- The patient exhibited significant hypoxemia, with oxygen saturation dropping to 82%.
Findings:
- Spectrophotometric analysis confirmed methemoglobinemia with a level of 8.9% in the patient.
- The condition resolved with supportive care, including a 48-hour intensive care unit stay.
Implications:
- Healthcare providers must be aware of the potential for methylene blue-induced methemoglobinemia.
- Vigilant monitoring for hypoxemia and cyanosis is essential in patients undergoing methylene blue testing.
- Early recognition and management of methemoglobinemia can prevent severe complications.

